Chromosomally mediated high-level gentamicin resistance in Streptococcus mitis
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منابع مشابه
Chromosomally mediated high-level gentamicin resistance in Streptococcus mitis.
Four blood culture isolates of Streptococcus mitis were found to be resistant to penicillin (MIC, 16 to 32 micrograms/ml) and gentamicin (MIC, 128 or 1,000 micrograms/ml), and the two antibiotics demonstrated a lack of in vitro synergy. As shown by polymerase chain reaction assays, the structural gene known to encode high-level gentamicin resistance in Enterococcus faecalis, Enterococcus faeciu...
متن کاملChromosomally and Extrachromosomally Mediated High-Level Gentamicin Resistance in Streptococcus agalactiae.
Streptococcus agalactiae (group B Streptococcus [GBS]) is a leading cause of sepsis in neonates. The rate of invasive GBS disease in nonpregnant adults also continues to climb. Aminoglycosides alone have little or no effect on GBS, but synergistic killing with penicillin has been shown in vitro. High-level gentamicin resistance (HLGR) in GBS isolates, however, leads to the loss of a synergistic...
متن کاملChromosomally and extrachromosomally mediated high-level gentamicin
27 Streptococcus agalactiae (group B Streptococcus, GBS) is a leading cause of sepsis in 28 neonates. The rate of invasive GBS disease in non-pregnant adults also continues to climb. 29 Aminoglycosides alone have little or no effect on GBS, but synergistic killing with penicillin 30 has been shown in vitro. High-level gentamicin resistance (HLGR) in GBS isolates, however, 31 leads to loss of a ...
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We report on the first occurrence of high-level gentamicin resistance (MICs > or = 512 microg/ml) in seven clinical isolates of Streptococcus pasteurianus from Hong Kong. These seven isolates were confirmed to be the species S. pasteurianus on the basis of nucleotide sequencing of the superoxide dismutase (sodA) gene. Epidemiological data as well as the results of pulse-field gel electrophoresi...
متن کاملHeterogeneity of plasmids determining high-level resistance to gentamicin in clinical isolates of Streptococcus faecalis.
Between November 1981 and October 1984, 48 of 3,458 clinical isolates of Streptococcus faecalis at the University of Michigan Hospital showed high-level (greater than 2,000 micrograms/ml) resistance to gentamicin, as well as to all other clinically available aminoglycosides. Thirteen percent of clinical isolates in the University of Michigan Hospital currently demonstrate this level of resistan...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1993
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.37.12.2740